Higher WBC count, serum creatinine (sCr), procalcitonin (PCT), lower MAP, Alb, higher incidence of hemorrhage, acute kidney injury (AKI), HE, kidney failure, brain failure, respiratory failure, circulation failure, systemic inflammatory reaction syndrome (SIRS), and higher clinical severity scores including CLIF-C ACLFs, CLIF-C OFs, SOFA scores were presented in patients with infection than non-infection patients. The gene discussed is ALB; the disease is hereditary elliptocytosis.