Our results depicted the association of FZ buffalo with oxidative stress, cardiovascular system, and immunity in were several KEGG pathways and GO terms, including HIF-1 signaling pathway, adherens junction, insulin secretion, arrhythmogenic right ventricular cardiomyopathy (ARVC), which were reported to be involved in the reaction to exercise. The gene discussed is INS; the disease is Arrhythmogenic right ventricular dysplasia.