Our results depicted the association of FZ buffalo with oxidative stress, cardiovascular system, and immunity in were several KEGG pathways and GO terms, including HIF-1 signaling pathway, adherens junction, insulin secretion, arrhythmogenic right ventricular cardiomyopathy (ARVC), which were reported to be involved in the reaction to exercise. This evidence concerns the gene INS and arrhythmogenic right ventricular cardiomyopathy.