More generic approaches for slowing disease progression or restoring visual function in IRDs are also under exploration, including AAV-mediated neuroprotection55 and reprogramming of photoreceptors through AAV-CRISPR/Cas9-mediated knockdown of NRL. 56 Moreover, targeting common neurodegenerative and neuroinflammatory disease pathways involved in the progression of IRDs, age-related macular degeneration, and glaucoma need to be explored. Here, NRL is linked to respiratory distress syndrome in premature infants.