Recently, a base editing strategy to correct a common SNP (rs1061170) associated with age-related macular degeneration (AMD) risk in the complement factor H (CFH) gene showed 21.5% C-to-T nucleotide correction efficiency with no detected off-target effects in a HEK293A cell line expressing the pathogenic CFH variant.25 The therapeutic promise of prime editors may be especially useful in addressing the heterogeneity of IRD mutations. This evidence concerns the gene CFH and age-related macular degeneration.