It was also demonstrated that the silencing of SLP 2 gene expression could drastically reduce the migration and invasive ability of glioma cells by inhibiting the transcriptional activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and repressing the expression levels of NF-κB target genes, including matrix metallopeptidase 9 [25]. The gene discussed is NFKB1; the disease is central nervous system cancer.