In particular, the betweenness of eight of the global proteins (SCARB1, PVR, EIF4E2, CEP135, SIGMAR1, TOR1AIP1, RAB14, and SAAL1) is 0 in the HIN before increasing by several orders of magnitude in the VIN, implying that these proteins are integrated into the network information flow at the onset of infection. The gene discussed is EIF4E2; the disease is infection.