PVR and infection: In particular, the betweenness of eight of the global proteins (SCARB1, PVR, EIF4E2, CEP135, SIGMAR1, TOR1AIP1, RAB14, and SAAL1) is 0 in the HIN before increasing by several orders of magnitude in the VIN, implying that these proteins are integrated into the network information flow at the onset of infection.