APOB and infection: However, it has to be underlined that ApoB-derived peptides were found to be ineffective against some S. aureus strains and Salmonella enteriditis, and this observation is in agreement with previous findings indicating that most natural cationic antimicrobial peptides do not appear to be highly optimized for direct antimicrobial activity, since it is likely that multiple modestly active peptides with a concomitant immunomodulatory activity work effectively in combination and/or when induced or specifically delivered to sites of infection.