This NUP98-NSD1-positive PDX model was analyzed in the 6th transplantation and showed AML with normal karyotype, while it was wildtype for genes frequently mutated in leukemia, such as FLT3, NRAS, NPM1, IDH1/2, and DNMT3A (Table S1). The gene discussed is FLT3; the disease is acute myeloid leukemia.