NSD1 and leukemia: To understand the cooperative potential of this fusion gene and its associated mutations in the development and progression of leukemia, we cloned NUP98-NSD1 into the MSCV-IRES-GFP vector and NRASG12D into the MSCV-IRES-BFP vector, respectively, and transduced 5-fluorouracil-treated mouse bone marrow cells (Figure S1A).