NUP98-NSD1 mice showed very low engraftment, while NUP98-NSD1+NRASG12D mice showed rapidly increasing engraftment over 12 weeks (Figure 2B), accompanied by an increased WBC count, anemia, and thrombocytopenia at 8 weeks after transplantation (Figure S2A–C). This evidence concerns the gene NSD1 and anemia (phenotype).