Mice transplanted with NUP98-NSD1-expressing cells developed leukemia with long latency and mice transplanted with NUP98-NSD1+NRASG12D-expressing cells developed aggressive leukemia with short latency (median survival 251 vs. 54 days after transplantation, p = 0.001; Figure 2C). The gene discussed is NSD1; the disease is leukemia.