In addition, Yang et al. demonstrated that the expression of GSK3β and phospho-Y216 GSK3β increased in patients with ALS compared to that in the controls, and that GSK3β and phospho-GSK3β immunoreactive neurons were mainly located in the frontal cortex and hippocampus of ALS patients [62]. The gene discussed is GSK3B; the disease is amyotrophic lateral sclerosis.