PDAC patients with Vav1-positive tumors have a worse prognosis compared to patients with Vav1-negative tumors [10,12], and the ability of Vav1 to promote the growth of pancreatic cancer cells was correlated to its best-known function as a guanosine exchange factor (GEF) [10]. The gene discussed is VAV1; the disease is familial pancreatic carcinoma.