IL-17 induces the production of cytokines (IL-6, IL-1), chemokines (IL-8, CCL-2, CCL-8, CCL-20, CXCL-2), matrix metalloproteinases (MMP-1, MMP-2, MMP-9) and other adhesion molecules by the dermal fibroblast and endothelial cells (ECs) of SSc patients, which perpetuate the inflammatory processes and, as mentioned above, contribute to fibrosis and vascular dysfunction-related processes [71,75,76,81,82]. The gene discussed is IL17A; the disease is systemic sclerosis.