Although some pathogenic mechanisms of SLE are still unknown, it has been widely reported that the main immunological events involved in the pathogenesis of SLE are the disbalance between apoptotic material production and its removal, the type I interferon (IFN) altered signaling and the T and B cells’ abnormal activation, which lead to autoantibody production. The gene discussed is IFNA1; the disease is systemic lupus erythematosus.