Cluster 1 was associated with a higher aneuploidy score, homologous recombination defects, and a higher frequency of APC and TP53 mutations (all p-values < 0.001), whereas cluster 2 was associated with a higher frequency of microsatellite instability, proximal tumor location, BRAF mutations, single nucleotide variant neoantigens, indel neoantigens, and non-synonymous mutations (all p-values < 0.001). The gene discussed is BRAF; the disease is neoplasm.