CST3 and diabetes mellitus: Further adjustment for well-established confounders such as BMI, smoking status, localization of OA, diabetes, maximum walking distance, total cholesterol, and cystatin C in model 2 led to only minimal reduction in estimates, with a HR of 1.64 (95% CI 1.12–2.38) for Q2 and a HR of 1.84 (95% CI 1.27–2.66) for Q3, and a HR of 2.69 (95% CI 1.82–3.96) for Q4, respectively.