In IgE-mediated FA, the immune response to food proteins that pass through the disrupted epithelial barrier is developed within a tissue environment governed by inflammatory cytokines that activates dendritic cells to in turn activate T-cells into a T helper 2 (Th2) phenotype, which then prime the production of allergen specific IgE by B lymphocytes. The gene discussed is IGHE; the disease is Friedreich ataxia.