In the same experimental model of depression in mice, the phosphorylation of GluN1 and GluA1 receptors (p-GluN1 (Ser896), p-GluA1 (Ser831)) was decreased in the hippocampal dentate gyrus and CA1 region, whereas the endogenous Sigma1R agonist DHEA (30 and 60 mg/kg, p.o.)restored the phosphorylation. This evidence concerns the gene SIGMAR1 and depressive disorder.