CD4 and neoplasm: Luo et al. [45] recommended that the λ-carrageenan injection that could repress malignant development in B16-F10 and 4T1 bearing mice and upgrade tumor resistant reactions by rising the tumor-infiltrating M1 macrophages number dendritic cell antigen “DCs” and extra stimulated CD4 + CD8 + T lymphocytes in the spleen.