CLU and Alzheimer disease: We showed a significant sex-dependent association of rs7982 with IR levels in three temporal lobe regions, suggesting that rs7982 may be an important factor underlying AD susceptibility by modulation of IR in the 5th exon of CLU. Interestingly, we observed that rs7982 might have a sex-specific effect on IR levels, with IR showing a significantly greater decrease in female AD patients relative to cognitively normal older adults (CN).