Moreover, endocytic uptake of amyloid-like WT TDP-43 fibrils in neuroblastoma cells, or increased levels of cytoplasmic-localized TDP-43 in neuroblastoma or iPSC-derived motor neuron cells, can provoke the formation of TDP-43 liquid-like foci that only in rare instances harbor classical SG marker proteins. The gene discussed is TARDBP; the disease is neuroblastoma.