NFKB1 and diabetic kidney disease: It is worth noting that, in DKD, ROS combine with NO to form peroxynitrites, a potent oxidant and cytotoxic agent, thereby declining the concentration of NO and causing an O2-/NO imbalance, which inhibits the activation of NF-κB pathway and the proliferation of vascular endothelial cells, leading to vascular endothelial injury [53,54,55].