Actually, in STZ injection mice model, Ming et al. observed that inhibition of NLRP3 inflammasome took the edge off hypertrophy of glomerular, glomerulosclerosis, expansion of mesangial, interstitial fibrosis, inflammation and expression of TGF-β1, as well as the activation of Smad3. Here, NLRP3 is linked to glomerulosclerosis.