NLRP3 and diabetic kidney disease: Immunofluorescence staining revealed that inhibition of NLRP3 inflammasome remitted the increasing expression of collagen I. Taken together, these emphasized that the generation of renal extracellular matrix (ECM) as well as interstitial fibrosis in DKD could be effectively suppressed by inhibition of NLRP3 inflammasome [17].