While this finding agrees with another reporting that HPV-5/-18 and BPV-1 E2 proteins do not influence the SMC6 abundance [12], it contrasts with studies of hepatitis B virus (HBV) wherein the master regulatory protein of HBV—HBx—was found to target SMC5/6 for degradation shortly after infection [8,9]. This evidence concerns the gene SMC5 and infection.