Analogously, the combined use of anti-PD-L1 and irradiation (12 Gy) in the mice model inoculated subcutaneously with TUBO (mammary tumor cells) and MC38 (colon adenocarcinoma cell line) induced apoptosis of MDSCs to limit their accumulation in the tumor microenvironment and restored the anti-tumor function of CD8, which in return eliminated MDSCs [59]. The gene discussed is CD8A; the disease is neoplasm.