Costimulatory molecules (CD80), intercellular adhesion molecule 1 (ICAM-1), stress ligands (NKG2DL), and death receptor Fas on the tumor surface are also upregulated after radiation, which makes the tumor cells more sensitive to the recognition and killing of cytotoxic T lymphocyte (Figure 1) [16,20,21,22]. Here, CD276 is linked to neoplasm.