Specially, HMGB1 plays a pro-inflammatory mediator role in producing inflammatory factors TNF, IL-1, IL-6, and IL-8 by stimulating monocytes, as well as binding to toll-like receptor 4 (TLR4) on DCs and decreasing the degradation of intracellular antigens to facilitate the presentation of tumor antigens [5,16,17]. Here, TLR4 is linked to neoplasm.