In addition to the mode of antigen presentation, the production of IFN is crucial for RT-induced immune activation and abscopal response, while the immanent IFN secretion of irradiated tumor cells relies on the opening of cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthase (cGAS)-stimulator of the interferon genes (STING) pathway and tumor microenvironment [5,89]. Here, CGAS is linked to neoplasm.