IGFBP5 and neoplasm: Other genes associated with the angiogenic process were observed to contribute to tumor dormancy, including tropomyosin, transforming growth factor beta 2 (TGF-b2), Eph receptor A5 (EphA5), histone H2BK, proline 4-hydroxylase alpha polypeptide I, and insulin-like growth factor binding protein 5 (IGFBP-5) [123].