An enrichment of specific cellular miRNAs, including miR-363, in EVs derived from CD40/IL-4-stimulated chronic lymphoblastic leukemia cells was observed, and autologous patient CD4(+) T cells were found to be capable of internalizing the CLL-EVs that target the immunomodulatory molecule CD69 [77]. This evidence concerns the gene IL4 and B-cell chronic lymphocytic leukemia.