It is our hypothesis that in the setting of COVID-19 and oxidative stress, patients with comorbidities may have compromised levels of GS and GCL, the enzymes involved in GSH synthesis For this reason, we suggest directly supplementing liposomal glutathione, instead of NAC as patients with deficient levels of GS and GCL will not be able to use NAC as substrate for GSH synthesis. Here, GCLC is linked to COVID-19.