ASPG and acute lymphoblastic leukemia: VTEs were also significantly more common in children in the high-risk ALL group compared to the standard or medium-risk groups (11.2% vs. 6.4%, p = 0.039) and in children treated with the AIEOP-BFM ALL 2009 protocol (including PEG-asparaginase) than in children treated with the ALL-IC BFM 2002 protocol (including native E. coli-asparaginase) (10.2% vs. 4.7% p = 0.001 for any VTE; and 3.0% vs. 1.0%, p = 0.010 for severe VTE).