In human intestinal cancer cell lines Caco-2/TC7 and SW480 and normal crypt-like HIEC-6 cells, PrPc interacts with the canonical Wnt pathway effectors β-catenin and transcription factor 7-like 2 (TCF7L2) in the cytoplasm and nucleus to upregulate their transcriptional activities [71]. The gene discussed is TCF7L2; the disease is intestinal cancer.