PRNP and frontotemporal dementia: Furthermore, various mutations of the PRNP gene have been identified to play an important role in clinical pictures imitating other neurodegenerative diseases including cerebral amyloid angiopathy (CAA) [290], frontotemporal dementia (FTD) [291,292,293,294,295], familial neuropsychiatric illness [296], Huntington’s disease [297], and familial AD [298].