ACSS2 and neoplasm: For example, acidic culture conditions can induce nuclear localization of the Sterol Regulatory Element-binding protein 2 (SREB2), driving the transcription of twelve pH-responsive genes including acetyl-CoA synthetase 2 (ACSS2), 3-hydroxy-3-methylglutaryl-CoA synthase 1(HMGCS1), farnesyl diphosphate farnesyltransferase (FDFT1), and low density lipoprotein receptor (LDLR) [53] that contribute to invasion [54] (ACSS2), proliferation [55] (FDFT1), increased growth rates [56] (HMGCS1), and advanced tumor grades [57] (LDLR).