BRD4 and malignant colon neoplasm: Additionally, the transcriptional regulator bromodomain-containing protein 4 (BRD4) had an increased abundance in colon cancer that promoted growth and invasion independently of its transcriptional targets, Myc and B-cell lymphoma 2 (BCL2), by stabilizing acetylated Snail and promoting proliferation through a post-translational regulatory mechanism [88].