To ascertain potential inhibitory activities of CMCO against COPD-relevant inducers of inflammation and oxidative stress in respiratory cells, we have generated a series of reporters of transcriptional activity of the following four stress-inducible transcriptional factors: p53, Nrf2, NF-κB, and AP-1 [16,17]. The gene discussed is NFKB1; the disease is chronic obstructive pulmonary disease.