HPN and obesity due to melanocortin 4 receptor deficiency: Specifically, in hypertension, increases were found in at least 20% of DataSets for ACE2, ADAM17, AGTR1, TMPRSS1, TMPRSS2, TMPRSS3, TMPRSS5, TMPRSS11A, and TMPRSS15. In contrast to the results seen in renal tissues, obesity did not appear to modulate the expression of any of these genes except for SDC4 in circulating immune cells.