Lastly, highly variable modulation was found in the context of CKD with or without hemodialysis with increases in ACE, ACE2, AGTR1, TMPRSS1, TMPRSS2, TMPRSS3, TMPRSS4, BDKRB1, BDKRB2, and most of the HSPGs in at least 25% of the DataSets. The gene discussed is TMPRSS3; the disease is chronic kidney disease.