Another key process in tumor angiogenesis is the activation of oncogenic pathways like the signal transducer and activator of transcription 3 (STAT3) signaling pathway, and the target of rapamycin (mTOR) pathway including Nuclear Factor Kappa B (NF-κB) and Wnt/β-catenin pathways, which further promote the release of proangiogenic factors [25]. Here, STAT3 is linked to neoplasm.