The knockdown of lincRNA AK001058 also decreased angiogenic cytokine expression of VEGF and Ang-2 in CRC through a hypermethylation of the metallopeptidase ADAM Metallopeptidase With Thrombospondin Type 1 Motif 12 (ADAMTS12) promoter [72]. Here, VEGFA is linked to colorectal carcinoma.