Curiously, only the PS2-N141I mutation has been used to generate AD mouse models based on PSEN2. In terms of the latter, we used two homozygous lines: the double Tg (2TG) B6.152H, also known as B6.PS2APP, and the single Tg (TG) PS2.30H [76]. Here, PSEN2 is linked to Alzheimer disease.