B6.152H mice have also been used in hemizygosity (B6.152) to study different aspects of the AD phenotype [158], or to generate TauPS2APP triple Tg mice, upon crossing the B6.152H line with the Tau-overexpressing pR5 line [159,160] that expresses the human tau-40 isoform under the Thy1.2 promoter [161]. The gene discussed is MAPT; the disease is Alzheimer disease.