Indeed, innate immune responses play an important role in the initial defense against adenovirus infection, but in some cases, excessive cytokine releases, such as interleukin-6 (IL-6), interleukin-8 (IL-8), or tumor necrosis factor alpha (TNF-α), have been reported to be associated with severe or fatal infections [15]. Here, CXCL8 is linked to adenoviridae infectious disease.