However, in our current studies, AXL knockdown resulted in p53 upregulation in three wild-type p53 mesothelioma cell lines (MESO924, MESO296, and MESO428) and one p53 mutant mesothelioma cell line (JMN1B), and overexpression of AXL inhibited p53 expression after cotransfection of AXL and TP53 (wild type) expression constructs in COS-7 cells or transfection with AXL construct alone in the 293T cell line. The gene discussed is TP53; the disease is mesothelioma.