Melanoma tumors can be classified as (i) PD-L1-positive, TIL-positive (“hot” tumors, 35%), (ii) PD-L1-negative, TIL-negative (“cold” tumors, 40%), (iii) PD-L1-negative, TIL-positive (20%) or (iv) PD-L1-positive, TIL-negative (5%) tumors [11,12]. Here, CD274 is linked to melanoma.