Interestingly, some of the hypomethylated cancer cells also produced high concentrations of inflammatory cytokines including IFNγ, IL-6 and IL-8 [107], suggesting that constitutive PD-L1 expression in epigenetically dysregulated cancers could be maintained, at least in part, by the IFNγ and/or IL-6-dependent feedback loop. This evidence concerns the gene IFNG and cancer.