CNR1 and pancreatic neoplasm: Regarding PDAC, activation of cannabinoid receptors, particularly CB2, was found to induce pancreatic cancer cell apoptosis without affecting the normal pancreas cells [31] and different synthetic receptor agonists, as WIN-55,212-2 (CB1 and CB2), ACEA (CB1), and JWH-015 (CB2), caused a substantial cell death of MiaPaCa-2 cell [32].