BRCA2 and familial pancreatic carcinoma: Moreover, in cancer, BRCA2 inactivation leads to pro-inflammatory cytokines production, that is a determinant for cancer cell survival [60], and several studies have investigated the expression profile of various cytokines in patients with PDAC and Nuclear Factor kB (NF-κB) activation pathways that have also been shown to be involved in pancreatic cancer development [61,62,63].