We observed one single m6A site near the stop codon in 7 microcephaly-related E-SMRs, including Brca2, Cep152, Ddx11, Nde1, Kif14, Stil and Cdk5rap2, 3 polymicrogyria-related E-SMRs (Eomes/Tbr2, Pax6 and Foxp2), and 3 megalencephaly-related E-SMRs (Gli3, Ccnd2 and Kif7) (Figure 7A, Supplementary Tables S5 and S6). The gene discussed is GLI3; the disease is microcephaly.