CFTR and cystic fibrosis: The phenotypic consequences of the c.3844T>C (p.Trp1282Arg, W1282R) variant, which is a thymidine–cytosine substitution in exon 22 of the CFTR gene, leading to the change of tryptophan-1282 by arginine in the second nucleotide-binding domain (NBD2) of the protein molecule, were described for the first time based on the total sample of 42 CF patients from the Russian Federation.