Age (adjusted HR = 2.9, CI 95% 1.2–7, p = 0.02), functional ability with IADL (adjusted HR = 0.4, CI 95% 0.19–0.97), p = 0.04), CRP level (adjusted HR = 2.8, CI 95% 1.3–5.9, p < 0.01), and platelet count (adjusted HR = 2.8, CI 95% 1.2–6.6, p = 0.02) were significantly associated with acute respiratory failure during hospitalization. The gene discussed is CRP; the disease is respiratory failure.