In an animal model of multiple sclerosis, BVA will induce nitric oxide synthase (iNOS) activity, activate p38 mitogen-activated protein kinase (MAPK) and promote NF-κB signaling pathways in the spinal cords of rats with acute myelin basic protein (MBP)(68-82)–induced experimental autoimmune encephalomyelitis (EAE). Here, MBP is linked to experimental autoimmune encephalomyelitis.