In addition, in the MPN group, chronic myelogenous leukemia cases that have very high number of leukocytes, and platelets showed lower expression of GSN in three cases, but increased expression in a case with chronic myelogenous leukemia in an accelerated phase that exhibited increased numbers of leukemic blasts like as in MDS-EB-2 (Figure 4E). Here, GSN is linked to myeloproliferative neoplasm.