Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates antioxidant machinery and expresses a variety of antioxidant genes, including heme oxygenase-1 (HO-1) and superoxide dismutase 2 (SOD2), which alleviate oxidative stress and inflammatory responses in liver diseases [5,6]. Here, HMOX1 is linked to liver disorder.