A number of mechanisms have been proposed by which BRD7 expression is downregulated in cancer (Table 1 and Table 2): these include increased methylation of the BRD7 promoter [45,78], microRNA-mediated degradation of BRD7 mRNA [32,44,79], and increased ubiquitination of the BRD7 protein by E3 ligases [46,80]. Here, BRD7 is linked to cancer.