The US Food and Drug Administration granted accelerated approval to selinexor in July 2019, a selective inhibitor of exportin 1, in combination with dexamethasone for the treatment of adult patients with relapsed/refractory multiple myeloma who have received ≥4 prior lines of therapy and whose disease is penta-refractory (i.e., ≥2 proteasome inhibitors, ≥2 IMiDs, and ≥1 anti-CD38 monoclonal antibody) [20]. The gene discussed is CD38; the disease is AL amyloidosis.