Lower expression of VGLL4 is usually associated with poor survival in several cancers, including those affecting the lung, breast, colon, bladder, pancreas and oesophagus; however, none of these findings provide an obvious reason why there was not a significant prognostic difference between patients with Q1 and Q4 levels of VGLL4, while there was when levels of VGLL4 were in the middle quartiles. The gene discussed is VGLL4; the disease is cancer.