KMT2A and acute myeloid leukemia: HOX and MLL-driven transformation of haematopoietic stem cells requires Wnt signalling, as AML was shown not to form in the absence of β-catenin otherwise [43] and, in addition to Wnt, a number of HOX and HOX antisense genes were significantly altered in their expression between patient subgroups, including adult poor and good, adult intermediate and good, and paediatric standard and low risk.