We searched the WGS data of the CFF individuals for missense and loss-of function variants within the known high-risk genes BRCA1 and BRCA2 for breast cancer, APC, MLH1, MSH2, MSH6, MUTYH, and PMS2 for colorectal cancer and HOXB13 for prostate cancer. This evidence concerns the gene MSH2 and Familial prostate cancer.