We searched the WGS data of the CFF individuals for missense and loss-of function variants within the known high-risk genes BRCA1 and BRCA2 for breast cancer, APC, MLH1, MSH2, MSH6, MUTYH, and PMS2 for colorectal cancer and HOXB13 for prostate cancer. The gene discussed is MSH2; the disease is prostate cancer.