GPX4 and type 2 diabetes mellitus: To further investigate the mechanism of glucose toxicity-induced ferroptosis in β cell of T2DM mice, the ferroptosis-associated protein was detected by Western blotting, and the result showed that xCT increased 2.3-fold as compared to the normal group (Figure 5F, p < 0.001) and GPX4 is significantly reduced, accounting for 20% of control and quercetin normalized the proteins level (Figure 5F, p < 0.001).