MUC16 and ovarian epithelial tumor: More specific biomarkers such as β-subunit of human chorionic gonadotropin (β-hCG), α fetoprotein, lactic dehydrogenase (LDH) may be useful for diagnosing malignant non-epithelial tumors.8On the other hand, there is scarce information in the current literature about the role of routinely measured biomarkers cancer antigen 125 (CA125) and carcinoembryonic antigen (CEA); and also more recently discovered biomarker Human Epididymis Protein 4 (HE4) in the preoperative diagnosis of non-epithelial ovarian tumors.