CD8A and infection: In mice chronically infected with LCMV cl13, T-betlow Eomeshigh cells accumulate with time after infection and show characteristics of exhaustion, such as high expression of PD-1, LAG-3, TIM3, TIGIT, CD39, CD160, CTLA-4, as well as reduced production of pro-inflammatory cytokines and only moderate proliferation potential as compared to T-bethigh Eomeslow CD8 memory T cells [7, 23].