An increasing number of candidate genes are associated to otitis media in humans and animals including Chd7, Eya4, Enpp1, Fbxo11, Lmna, Mcph1, Oxgr1, Slc25a21, Splunc1, Tgif1, Tlr4, TNFA among others [1–9]. The gene discussed is TLR4; the disease is otitis media.