Therefore, we tested the mRNA level of CYR61 and CTGF, and found that YAP decreased the mRNA level of CYR61, while the mRNA level of CTGF was significantly increased (Supplementary Figure 4), indicating that other YAP-targeted genes might also be involved in D-gal-induced senescence of GBM cells. The gene discussed is CCN2; the disease is glioblastoma.