It has been reported that there is a close correspondence between stemness enhancement of lung cancer cells and the tumor microenvironment (TME) that includes cancer cells, immune cells, etc10 The rapid growth of tumors leads to insufficient oxygen supply in the microenvironment, which results in the upregulation of hypoxia‐inducible factor‐1α (HIF‐1α). The gene discussed is HIF1A; the disease is neoplasm.